1610Pervasive B cell Activation during Viremic HIV-1 Infection but Effective Responses with Appropriate Stimulation in vitro
نویسندگان
چکیده
Effective Responses with Appropriate Stimulation in vitro Lindsay Nicholson, MD; Harsh Pratap, MS; Elisabeth Bowers, PhD; Edward M. Gardner, MD; Timothy Wright,; Edward Janoff, MD; Internal Medicine/ Infectious Diseases, University of Colorado Denver, Aurora, CO; Infectious Diseases, University of Colorado Denver, Aurora, CO; University of Colorado Denver, Aurora, CO; Denver Health and Hospital Authority, Denver, CO; University of Colorado, Anschutz Medical Center, Aurora, CO
منابع مشابه
B Cell Responses to HIV Antigen Are a Potent Correlate of Viremia in HIV-1 Infection and Improve with PD-1 Blockade
Infection with Human Immunodeficiency Virus Type 1 (HIV-1) induces defects of both cellular and humoral immune responses. Impaired CD4+ T cell help and B cell dysfunction may partially explain the low frequency of broadly neutralizing antibodies in HIV-infected individuals. To understand the extent of B cell dysfunction during HIV infection, we assessed the level of B cell activation at baselin...
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Persistent immune activation is a hallmark of chronic viremic HIV-1 infection. Activation of cells of the innate immune system, such as NK cells, occurs rapidly upon infection, and is sustained throughout the course of the disease. However, the precise underlying mechanism accounting for the persistent HIV-1-induced activation of NK cells is poorly understood. In this study, we assessed the rol...
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Aberrant expression of regulatory receptors programmed death-1 (PD-1) and B- and T-lymphocyte attenuator (BTLA) is linked with dysregulation and exhaustion of T lymphocytes during chronic human immunodeficiency virus type 1 (HIV-1) infection; however, less is known about whether a similar process impacts B-lymphocyte function during HIV-1 infection. We reasoned that disruption of the peripheral...
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HIV infection induces a wide array of B cell dysfunctions. We have characterized the effect of plasma viremia on the responsiveness of B cells to CD4(+) T cell help in HIV-infected patients. In HIV-negative donors, B cell proliferation correlated with CD154 expression on activated CD4(+) T cells and with the availability of IL-2, whereas in HIV-infected viremic patients, reduced B cell prolifer...
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Human immunodeficiency virus (HIV) infection leads to numerous perturbations of B cells through mechanisms that remain elusive. We performed DNA microarray, phenotypic, and functional analyses in an effort to elucidate mechanisms of B cell perturbation associated with ongoing HIV replication. 42 genes were up-regulated in B cells of HIV-viremic patients when compared with HIV-aviremic and HIV-n...
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عنوان ژورنال:
دوره 1 شماره
صفحات -
تاریخ انتشار 2014